Michelle’s master research focused on the use of molecular docking approaches in conjunction with synthesis for the rational drug design of anti-cholinergic agents for the the treatment of Alzheimer’s disease. MIchelle’s current PhD research focuses on the use of Design of Experiment (DoE) modelling to expedite and streamline process optimisation and compound library synthesis under flow conditions. Michelle also studies the use of DoE as a tool to design green synthesis routes which she is currently applying to development of flow-based process routes to active pharmaceutical ingredients for the treatment of idiopathic pulmonary fibrosis.


The synthesis of analogues and bioisosteres of the acetylcholinesterase inhibitor Donepezil in an attempt to identify novel anti-Alzheimer’s agents


  1. 47th IUPAC World Chemistry Congress, Paris, France, July, 2019: The synthesis of analogues and bioisosteres of the acetylcholine inhibitor Donepezil in attempt to combat Alzheimer’s disease, A.M. Reinhardt, C.J. van der Westhuizen, J.-L. Panayides, D.L. Riley
  2. SAAWK Conference, Pretoria, South Africa, November 2017: Amidasie van die trisikliese 5,6-dimetoksie-8H-ideno[1,2-d]tiazol-2-amien raamwerk met N-bensiel ringe as potensiele inhibeerders van asetiel cholienesterase in Alzheimer se siekte, A.M. Reinhard*, D.G. van Greunen, C.J. van der Westhuizen, J-L. Panayides, D.L. Riley – Poster Prize