Research Area (Doctoral)
The development of continuous flow processes for the manufacture of chemical entities in addition to offering advantages over batch chemistry also affords the researcher the opportunity to to perform inline downstream processing and purification often facilitated through the use of of solid supported reagents and scavengers. The development of solid supported catalysts is of particular interest as it affords the means to perform reactions with precise control to catalyst exposure and it potentially negates the need for further purification steps to remove spent catalyst from the reaction mixture. Ian’s research focuses on the development of flow based routes to pharmaceuticals with an emphasis on the incorporation of heterogeneous catalyst systems utilising monolithic supports.
3. A hemilabile and cooperative N-donor functionalized 1,2,3-triazol-5-ylidene ligand for selective and base-free rhodium(I) catalyzed alkyne hydrothiolation reactions, Chemistry – A European Journal, 2016, 23, 1393-1401, I. Strydom, G. Guisado-Barrios, I. Fernández, D.C. Liles, E. Peris, D.I. Bezuidenhout.
Cooperation in action! A ligand- assisted acid-base thiol-activation strategy is reported for the regioselective hydrothiolation of alkynes mediated by a rhodium(I) catalyst.
2. Synthesis and electrochemical investigation of chromium(0) ferrocenyl-substituted carbene complexes Inorganica Chimica Acta, 2014, 423, 184-192, D.I. Bezuidenhout, B. van der Westhuizen, I. Strydom, P.J. Swarts, J.C. Swarts and I. Fernández.
1. Electrochemical illumination of thienyl and ferrocenyl chromium(0) Fischer carbene complexes, Dalton Transactions, 2013, 42(15), B. van der Westhuizen, P.J. Swarts, I. Strydom, D.C. Liles, I. Fernández, J.C. Swarts and D.I. Bezuidenhout
2016 Frank Warren (Rhodes University) “The steroeselective continuous flow synthesis of Fluoxetine utilising formaldehyde gas”