New Paper – Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer’s disease

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We have recently publicshed a follow-up paper to our 2017 in which we identified a potent anti-cholinergic agent. In this paper we have been able to maintain good activity while reducing the metabolical liability of the active species (European Journal of Medicinal Chemistry 2019, 179, 680-693). Congratulations to Divan van Greunen who performed the synthetic work and Johan van der Westhuizen who was responsible for the in silico studies.